Press "Enter" to skip to content

A Protein Found That Controls Self-Renewal Ability In Stem Cells

Lately, scientists from UCLA (University of California, Los Angeles) discovered a connection amid a protein and the ability to self-renew by human blood stem cells. The research team reported that triggering the protein induces blood stem cells to self-renew up to twelve times in laboratory conditions. Proliferating blood stem cells in circumstances outside the human body can significantly improve treatment alternatives for blood cancers such as leukemia and for several inherited blood diseases. Dr. Hanna Mikkola from the UCLA studied blood stem cells for over 20 Years. The new study was published in the journal Nature.

Reportedly, the blood stem cells are present in the bone marrow, wherein they self-renew and differentiate to form all kinds of blood cells. For decades, bone marrow transplants have been utilized to cure people having some diseases of the immune system or the blood. When the blood stem cells are extracted from the bone marrow and kept in laboratory dishes, they rapidly lose their capability to self-renew, and they either differentiate into other blood cell types or die. To discover what leads to self-renewable ability in blood stem cells in the lab, the scientists examined the genes that disabled as the human blood stem cells lose their potential to self-renew. They discovered that the expression of MLLT3 gene was closely linked with blood stem cells’ ability to self-renew.

On a similar note, recently a study showed that stem cell provides clues for maximizing bone marrow transplants and more. The bone marrow transplants offer the best treatment options for several types of cancers, immune diseases, and blood disorders. Despite the fact that 22,000 of these procedures are done every year in the U.S., much research is needed on how they work. A new Stanford and USC study, carried in mice, intensifies the mystery, demonstrating that successfully transplanted stem cells do not work “normally” as in a fit person without a transplant. The study findings were presented in PNAS (Proceedings of the National Academy of Sciences).

Ramona Bohn
Ramona Bohn Author
Content Writer At Medical Device News

Having more than 4 years of experience in the industry, it has been a couple of years for Ramona to be at
Medical Device News. She is responsible for anything that takes place in the Health Department, making her the sole leader of the department. She has also grabbed a couple of certificates to justify her role. Ramona appreciates a cool coffee shop, finds learning incredibly motivating, and is an aspirant urban farmer in her apartment.

Be First to Comment

Leave a Reply

Your email address will not be published. Required fields are marked *